Episode 1: Dr. Mercy tries to remove Price's relationship-ruining lipoma, Ashley's case of neurofibromatosis is 1 of the worst in the country, and Becca’s birthmark covers most of her face.
Episode 2: Joseph's neck lipoma gets in the way constantly, Rachel's condition gives her a full beard, and Summer has 7 cysts, including her "unicorn horn".
Episode 3: Tiffany’s rare condition is so painful that it has isolated her at home, Brad's face is covered in nodules thanks to a 1-in-a-million condition, and Lydia's sweating holds her back.
Episode 4: Jorge's rhinophyma interferes with his breathing, Tracy's body is covered in hundreds of lipomas, and Cha comes to Dr. Mercy with bumps on her face that are draining her confidence.
Episode 5: Ramon will need a skin graft if the keloids on the back of his head are removed, Lauren has bumps both inside and outside of her body, and Tiana has what looks like 4 breasts.
Episode 6: Tiana returns to Dr. Mercy, Michael wants his giant patches of skin tags removed for his 40th birthday, and Chandra's lipoma is a drain on her physically and emotionally.